Synthesis and characterization of gallium (III) and bismuth (III) complexes beraring bioactive ligands
Bismuth (III), gallium (III), anticancer, antibacterial, ciprofloxacin, hydroxyquinoline
Nowadays there has been an expansion of gallium and bismuth compounds with therapeutic potential. Gallium (III) is able to mimic iron(III) by replacing it at various iron-dependent sites, causing disruption of cell replication, which is an important mechanism against tumor cell proliferation. Bismuth(III), in turn, has been used to treat gastrointestinal disorders, ulcers and bacterial infections, especially those caused by the bacterium Helicobacter pylori. Bismuth has the great advantage of low cytotoxicity. Thus, this work consists of combining the pharmacological properties of these metallic ions with bioactive ligands.