Banca de DEFESA: JANIA DOS SANTOS ROSARIO

Uma banca de DEFESA de MESTRADO foi cadastrada pelo programa.
DISCENTE : JANIA DOS SANTOS ROSARIO
DATA : 05/06/2020
HORA: 14:00
LOCAL: https://conferenciaweb.rnp.br/events/defesa-de-mestrado-jania-dos-santos-rosario
TÍTULO:

Synthesis and characterization of gallium (III) and bismuth (III) complexes beraring bioactive ligands

PALAVRAS-CHAVES:

nalidixic acid; ciprofloxacin; 8-hydroxyquinoline; bismuth; gallium

PÁGINAS: 60
GRANDE ÁREA: Ciências Exatas e da Terra
ÁREA: Química
SUBÁREA: Química Inorgânica
ESPECIALIDADE: Química Bio-Inorgânica
RESUMO:

Nowadays there has been an expansion of gallium and bismuth compounds with therapeutic potential. Gallium (III) is able to mimic iron(III) by replacing it at various iron-dependent sites, causing disruption of cell replication, which is an important mechanism against tumor cell proliferation. Bismuth(III), in turn, has been used to treat gastrointestinal disorders, ulcers and bacterial infections, especially those caused by the bacterium Helicobacter pylori. Bismuth has the great advantage of low cytotoxicity. Thus, this work consists of combining the pharmacological properties of these metallic ions with bioactive ligands.

Thus, this work consists of combining the pharmacological properties of these metal ions with that of bioactive ligands. This work presents the synthesis, physico-chemical characterization and spectroscopic studies of three new compounds having bismuth(III) or gallium(III) as the metal center with the quinolone families (nalidixic acid and ciprofloxacin) and quinolines ( 8-hydroxyquinoline). The compounds are: [BiCl₃(CFX)₃] –1, [Bi(8-hq)₂(Hcip)]Cl‧2H₂O - 2, [Ga(NDX)₃]∙4H₂O - 4. One of the compounds present in this work is already known in the literature, [Ga(8-hq)₃] - 3 and was prepared to be used in the future as a reference for cytotoxic tests.

MEMBROS DA BANCA:
Interno - EUDES LORENCON
Presidente - PRISCILA PEREIRA SILVA CALDEIRA
Externo à Instituição - WILLIAN XERXES COELHO OLIVEIRA - UFMG