Banca de QUALIFICAÇÃO: LORRANE DINIZ DE CARVALHO SILVA
Uma banca de QUALIFICAÇÃO de MESTRADO foi cadastrada pelo programa.STUDENT : LORRANE DINIZ DE CARVALHO SILVA
DATE: 01/04/2024
TIME: 09:30
LOCAL: Campus Gameleira, Auditório
TITLE:
COPPER(II) COMPLEXES WITH IMIDAZOLE LIGANDS: Preparation, Characterization, and Biological Assays.
KEY WORDS:
Metal Complexes, Theophylline, Imidazole, Imidazole ligands, Copper.
PAGES: 74
BIG AREA: Ciências Exatas e da Terra
AREA: Química
SUBÁREA: Química Inorgânica
SPECIALTY: Química Bio-Inorgânica
SUMMARY:
Drugs are compounds of extreme importance in maintaining human health, and the discovery of new drugs is a continuous social demand in the face of emerging diseases, resistance to existing therapeutic treatments, as well as the lack of effective medications in combating certain illnesses. Several studies have been conducted in the search for metal complexes with biological activity that are more selective and less toxic than their free ligands.
In this work, two copper(II) metal complexes were synthesized and characterized: complex 1, [Cu(C7H7N4O2)2(C3H4N2)2(H2O)], and complex 2, [Cu(C7H7N4O2)(C3H4N2)3(H2O)] Cl.H2O. The complexes were characterized by elemental analysis, conductometric measurements, vibrational spectroscopy in the IR region, and electronic spectroscopy in the UV−Vis region. Complex 1 was also characterized by thermal analysis and powder X-ray diffraction. Slow evaporation of a solution of complex 2, in MeOH and H2O, led to the formation of single crystals whose structure was determined by single-crystal X-ray diffraction.
The ability of complex 2 to promote oxidative cleavage of plasmid DNA was studied by agarose gel electrophoresis and showed that 2 has the ability to cleave plasmid DNA.
Keywords: Metal Complexes, Theophylline, Imidazole, Imidazole ligands, Copper.
COMMITTEE MEMBERS:
Presidente - PRISCILA PEREIRA SILVA CALDEIRA
Interna - RAQUEL VIEIRA MAMBRINI